Pomegranates prefer a semi-arid mild-temperate to subtropical climate and are naturally adapted to regions with cool winters and hot summers. A humid climate adversely affects the formation of fruit. The tree can be severely injured by temperatures below 12 F. In the U. S. pomegranates can be grown outside as far north as southern Utah and Washington, D.C. but seldom set fruit in these areas. The tree adapts well to container culture and will sometimes fruit in a greenhouse.

After opening the pomegranate by scoring it with a knife and breaking it open, the arils (seed casings) are separated from the peel and internal white pulp membranes. Separating the red arils is simplified by performing this task in a bowl of water, wherein arils sink and pulp floats. It is also possible to freeze the whole fruit in the freezer, making the red arils easy to separate from the white pulp membranes. The entire seed is consumed raw, though the watery, tasty aril is the desired part. The taste differs depending on subspecies of pomegranate and its ripeness.